Mycosis Fungoides and Renal Cell Carcinoma: A Paraneoplastic Syndrome

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FM is an interesting idiopathic skin condition that commonly appears as penetrated plaques, knobs, hypopigmented or erythematous patches, and eshcolored follicular papules. Examples of unusual presentations include alopecia areata-like symptoms, scarring alopecia, folliculitis, acneiform eruptions, linear lesions that follow Blaschko lines, and urticaria-like follicular mucinosis. The face, head, and neck are frequently affected in primary FM, while the trunk and limbs show extensive lesions. However, clinical characteristics are insufficiently specific to distinguish between the benign primary type and the secondary form associated with mycosis fungoides. As a result, follow-up is essential. A 16-year-old girl had a patch on the right side of her forehead that had been growing steadily over the past two years and was erythematous and somewhat irritating. Both the patient's upbringing and prior medical history were normal.

Well-defined, alopecic, and erythematous patch measuring 1 by 2 cm with significant follicular plugs in the middle was discovered during a dermatological examination. Around the lesion, a small ring of mildly hypopigmented skin was seen. A general physical exam revealed nothing unusual. Complete blood count, erythrocyte sedimentation rate, liver and kidney function tests, and urinalysis were among the laboratory tests that all fell within the normal range for. There were no organomegaly, enlarged lymph nodes, or any abnormal signs on the chest x-ray or belly ultrasound. There was a skin punch biopsy done. A portion of the sample that underwent Hematoxylin and Eosin (H&E) staining exhibited a mixed inflammatory infiltration that was primarily made up of lymphocytes and included and surrounded the follicular epithelium as well as a minor focal follicular spongiosis. The mucinous character of the infiltration in the follicular epithelium was revealed by alcian blue staining. The histopathology analysis revealed FM characteristics. An accurate diagnosis of follicular mucinosis was obtained based on the results of the clinical and histological testing